Why Pragmatic Free Trial Is Fast Becoming The Most Popular Trend For 2…

Stephany Gatlin 0 14 00:34
Pragmatic Play Free Trial

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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are typically ordered by policymakers and practitioners to help inform their decisions. They can be used to determine the causality of an intervention and its effects. However, they should not be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a practical trial which includes recruitment, design and delivery of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.

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